Endocrine System - MCAT Biological and Biochemical Foundations of Living Systems

Of all the hormones listed, antidiuretic hormone (ADH) is the only one that neither acts on, nor is released by, the adrenal cortex. ADH is released from the posterior pituitary and causes the kidneys to retain more water.

Aldosterone (a mineralcorticoid) and cortisol (a glucocorticoid) are both incorrect choices because they are released by the adrenal cortex and would be greatly affected by trauma to that area. ACTH is released by the anterior pituitary and acts to stimulate the adrenal cortex; these hormones act as part of a negative feedback chain, so damage to the target area would temporarily cause more ACTH to be produced. The same goes for CRH, which is released by the hypothalamus and stimulates secretion of ACTH.

Endocrine glands secrete hormones into the blood stream, lined with endothelium, allowing them to travel through the blood and to act at a distant site. Exocrine organs, in contrast, secrete products into lumens that are lined with epithelium.

Mammary glands are used in lactation. Because the milk is not secreted into the blood, the mammary glands are not endocrine glands.

The hypothalamus releases hormones into the blood, such as corticotropin-releasing hormone (CRH). The pituitary releases hormones such as prolactin. The adrenal gland secretes hormones such as cortisol.

The adrenal medulla, derived from neural crest cells, is responsible for making and releasing epinephrine and norepinephrine. Epinephrine and norepinephrine are responsible for increasing heart rate and activating the sympathetic nervous system when released.

In contrast, the adrenal cortex is derived from mesoderm and releases steroid hormones like aldosterone and cortisol. Corticotropin-releasing hormone is made by the parvocellular neurons of the hypothalamus.

Epinephrine and norepinephrine are released by the neuroendocrine cells of the adrenal medulla. In times of stress and sympathetic nervous system activation, the adrenal medulla will release epinephrine to cause blood vessel constriction. These hormones allow for the "fight-or-flight" response.

In contrast, the adrenal cortex will secrete cortisol and other mineralcorticoids in response to long-term stress. These hormones are not involved in the fight-or-flight response, and rather serve to prepare the body to endure prolonged harsh conditions, such as dehydration, starvation, and extreme temperatures. Adrenocorticotropic hormone is released from the anterior pituitary to stimulate the adrenal cortex.

Growth hormone and thyroid-stimulating hormone do not interact with the adrenal gland.

Hormones cortisol and aldosterone are synthesized in the adrenal glands. Adrenal glands are made up of the adrenal cortex and the adrenal medulla. Adrenal medulla is involved in the synthesize of catecholamines (epinephrine and norepinephrine) whereas adrenal cortex synthesizes mineralocorticoids (aldosterone), glucocorticoids (cortisol), and androgens (testosterone, DHT, and DHEA).

Aldosterone is released upon stimulation from the renin-angiotensin system and serves to increase reabsorption of sodium in the collecting ducts of the kidney. Cortisol is released due to stress and serves to increase the metabolic rate.

Luteinizing hormone is produced and secreted by the anterior pituitary gland.

Antidiuretic hormone is produced by the hypothalamus, but secreted by the posterior pituitary gland. Epinephrine is produced by the adrenal medulla; aldosterone is produced by the adrenal cortex. Thyroxine (T4) is produced by the thyroid.

Androgens and estrogens, the sex hormones, feedback to inhibit somatotropins, the growth hormones. In humans, the sex hormones are produced in puberty, disabling the growth plates and halting growth.

Positive feedback describes an event in which a pathway generates a response that further triggers the pathway, increasing the pathway effects. In contrast, negative feedback occurs when a pathway generates a response to inhibit the pathway origin, diminishing the pathway effects. Negative feedback is a common control mechanisms in the body to maintain homeostasis, while positive feedback is inherently designed to disrupt homeostasis.

Fever during illness is enhanced via a positive feedback system that only ends once the illness begins to alleviate. Similarly, contractions during labor will intensify via positive feedback oxytocin stimulation until the child is born. Osteoporosis is caused by an imbalance in the negative feedback system that controls blood calcium. This imbalance simply means that bone is lost more than it is gained, and is still an example of negative feedback.

Thyroid-stimulating hormone (TSH) levels would be decreased.

The thyroid hormones T3 and T4 act in a negative feedback loop to regulate thyroid activity. Release of TSH increases thyroid activity, while release of the thyroid hormones decreases thyroid activity by suppressing further release of TSH. Since the thyroid is overstimulated in Grave's Disease, excess T3 and T4 are being produced. These hormones will act on the feedback loop to suppress TSH release, lowering TSH levels in individuals with this disease. Since the antibodies bind to the TSH receptors, there are increased levels of T3 and T4 in the body, which negatively inhibit the production of TSH because the body is already flooded with the products of TSH action.

Triiodothyronine (T3) employs a negative feedback mechanism, meaning that when blood serum concentrations of T3 become too high, receptors on the thyroid gland inhibit the release of additional T3.

In contrast, a positive feedback mechanism would encourage additional release of a hormone when levels are high, resulting in an exponential increase in the hormone effects. An example of a positive feedback mechanism is the release of oxytocin during childbirth to help the uterus contract.

Oxytocin employs a positive feedback mechanism, meaning that existing levels of oxytocin encourage additional release of oxytocin. This results in an exponential increase in the hormone's effects.

In contrast, a negative feedback mechanism would prevent additional release of a hormone when levels of the existing hormone were too elevated. This results in stable homeostasis around a constant hormone concentration in the blood.

Injecting insulin into the body delivers it directly into the bloodstream, while consuming an insulin pill would require it to pass through the gastrointestinal tract. In the gut, the pill would be degraded first and then absorbed into the bloodstream. This entire process would result in a small amount of insulin circulating in the blood, and therefore be much less effective than an insulin injection. Additionally, injecting insulin directly allows more rapid administration of a more consistent dose.

Calcitonin lowers plasma calcium, while parathyroid hormone (PTH) increases it. Insulin and glucagon are responsible for blood glucose, not calcium.

Growth hormone is secreted by the anterior pituitary and is responsible for increased metabolism and cell growth. Growth hormone increases glucose and free fatty acid levels in the blood, increasing substrates for metabolism for other cells in the body.

Significant amount of blood loss results in a sudden and large drop in blood pressure due to the decreased fluid volume in the body. To compensate for this change, the body will attempt to increase fluid retention. This is directly accomplished by increasing the level of ADH (anti-diuretic hormone) that allows reabsorption of water in the kidneys. Therefore, increased ADH level is the best response.

This question requires knowledge of the negative feedback loop between the anterior pituitary hormones (FSH and LH) and the sex hormones (estrogen and progesterone). Prior to menopause, FSH and LH production is inhibited by estrogen production in the ovaries. When ovarian estrogen production decreases, during menopause, FSH and LH levels increase uninhibited.

Calcitonin decreases blood calcium levels, while parathyroid hormone increases blood calcium levels.

Aldosterone functions to make the collecting duct and distal convoluted tubule in the kidneys to make them more permeable to Na+, Cl–, K+, and H+. When Na+ and Cl– are reabsorbed, water follows them into the blood, thus increasing total blood volume and raising blood pressure.

FSH, LH, estrogen, and progesterone all increase around ovulation to make an environment in the uterus that will be healthy if fertilization occurs. Prolactin promotes milk production at the end of pregnancy and while a mother is breast feeding a child.

When an a meal is consumed, the digestive system is stimulated. This causes the release of secretin and cholecystokinin, hormones that are involved in digestion. Once glucose is in the bloodstream, it interacts with beta cells and causes the release of insulin. Insulin enters the bloodstream and stimulates widespread expression of the GLUT-4 receptor. Glucagon, on the other hand, counters the effects of insulin in a negative feedback loop and would not be expected to increase after a meal is consumed.