Pharmacogenomics Practice Test

A 27-year-old Southeast Asian female (55 kg) is prescribed carbamazepine for trigeminal neuralgia. Current medications: none. Pharmacogenomic results: HLA-B*15:02 positive. Labs: serum creatinine 0.7 mg/dL, alanine aminotransferase 16 units/L. Allergies: none. Which medication is most appropriate for this patient given their genetic profile?

A 33-year-old White male (82 kg) is being started on azathioprine 2 mg/kg/day for Crohn disease. Current medications: prednisone 20 mg by mouth daily (tapering). Pharmacogenomic results: TPMT *3A/*3A (no function). Labs: white blood cell count 6.2 x $10^3$/µL, hemoglobin 14.0 g/dL, platelets 250 x $10^3$/µL, alanine aminotransferase 19 units/L. Allergies: none. Which action should the pharmacist take considering the patient's pharmacogenomic profile?