All GRE Subject Test: Biology Resources
Example Questions
Example Question #1 : Understanding Hormone Functions
The interaction between blood pressure and kidney function in humans requires coordination by the renin-angiotensin-aldosterone system (RAAS). This system involves the dynamic interplay of the kidneys, lungs, and blood vessels to carefully regulate sodium and water balance.
A normal human kidney has cells adjacent to the glomerulus called juxtaglomerular cells. These cells sense sodium content in urine of the distal convoluted tubule, releasing renin in response to a low level. Renin is an enzyme that converts angiotensinogen to angiotensin I (AI). AI is converted to angiotensin II (AII) by angiotensin converting enzyme (ACE) in the lung.
AII stimulates aldosterone secretion in the zona glomerulosa of the adrenal gland. Aldosterone then acts to upregulate the sodium-potassium pump on the basolateral side of distal tubule epithelial cells to increase sodium reabsorption from the urine, as well as increasing potassium excretion.
Renin is most likely to drive the formation of angiotensin I from angiotensinogen by doing which of the following?
I. Increasing the concentration of angiotensinogen
II. Lowering the activation energy of the reaction from angiotensinogen to angiotensin I
III. Stabilizing the angiotensin I molecule to lower the energy of the products
I only
II and III
III only
II only
I,II, and III
II only
Renin, as the passage establishes, is an enzyme. Enzymes always work by leaving the thermodynamic energies of the products and reactants the same, but lower activation energy of the reaction. Angiotensinogen is released by the liver, and converted by renin to angiotensin I. Renin does not directly act on the liver to stimulate angiotensinogen release.
Example Question #1 : Endocrine System
What is the name of the hormone responsible for raising blood calcium levels?
Glucagon
Calcitonin
Parathyroid hormone
Thyroxine
Parathyroid hormone
Blood calcium levels are controlled primarily by two hormones: parathyroid hormone and calcitonin. Calcitonin is synthesized by the thyroid gland and decreases blood calcium levels. Parathyroid hormone acts as an antagonist to calcitonin and raises blood calcium levels.
Thyroxine, or T4, is a thyroid hormone involved in increasing basal metabolic rate. Glucagon stimulates the liver to release glucose into the blood, and raise blood glucose levels.
Example Question #1 : Endocrine System
What is the purpose of antidiuretic hormone in the body?
Raises the basal metabolic rate
Concentrates the urine
Lowers the blood pressure
Increases blood calcium levels
Concentrates the urine
Antidiuretic hormone is released by the posterior pituitary gland, and acts on the kidneys in order to concentrate the urine. Alcohol can inhibit ADH, which can result in excessive urine production and potential dehydration.
Example Question #3 : Understanding Hormone Functions
Which of the following hormones will increase cortisol secretion in a normal individual?
Luteinizing hormone
Adrenocorticotropic hormone
Thyroid stimulating hormone
Aldosterone
Adrenocorticotropic hormone
Cortisol is secreted by the adrenal gland. We need to identify the hormone responsible for stimulating the adrenal gland and prompting it to release cortisol. This job is accomplished by adrenocorticotropic hormone (or ACTH). While aldosterone is secreted by the adrenal gland, it does not impact the release of cortisol to any significant degree.
Example Question #4 : Understanding Hormone Functions
Which of the following features would you expect to see in an individual with a deficient posterior pituitary gland?
Dehydration
Low testosterone levels
Low blood calcium levels
Reduced basal metabolic rate
Dehydration
The two main hormones of interest that are secreted by the posterior pituitary gland are antidiuretic hormone (ADH) and oxytocin. Antidiuretic hormone plays a key role in retaining water at the level of the kidney. In patients with no ADH, fluid retention is severely diminished. Symptoms of this include frequent urination, hyperosmolality, and dehydration.
Example Question #2 : Endocrine System
Which gland releases hormones that help regulate blood glucose levels?
Anterior pituitary gland
Pancreas
Parathyroid gland
Adrenal cortex
Pancreas
The two major hormones that control blood sugar levels are glucagon and insulin. Glucagon helps raise blood glucose levels, while insulin decreases blood sugar levels. Both of these hormones are created and secreted by the pancreas.
The parathyroid gland secretes parathyroid hormone, which stimulates the synthesis of bone matrix to lower blood calcium levels. The adrenal cortex releases glucocorticoids, such as aldosterone, cortisone, and cortisol. The anterior pituitary gland secretes a number of hormones, including adrenocorticotropic hormone, thyroid-stimulating hormone, and growth hormone.
Example Question #1 : Endocrine System
Which gland releases oxytocin and antidiuretic hormone?
Posterior pituitary gland
Thyroid gland
Adrenal cortex
Anterior pituitary gland
Posterior pituitary gland
The pituitary gland has two separate sections: the anterior and posterior lobes. The anterior pituitary gland releases, among other hormones, growth hormone, prolactin, and thyroid-stimulating hormone. The posterior pituitary gland only releases two hormones: oxytocin and antidiuretic hormone. These hormones are synthesized in the hypothalamus and transferred to the posterior pituitary for release.
The thyroid gland releases the thyroid hormones T3 and T4, as well as calcitonin. The adrenal cortex secretes glucocorticoids, such as aldosterone, cortisone, and cortisol.
Example Question #7 : Endocrine System
Adrenocorticotropic hormone will enter the blood stream, and act on which structure in the body?
Liver
Pituitary gland
Kidney
Adrenal gland
Adrenal gland
Adrenocorticotropic hormone (ACTH) is secreted by the anterior pituitary gland. It then travels and stimulates the adrenal gland cortex to release its hormones.
Example Question #8 : Endocrine System
Which endocrine gland releases aldosterone?
Posterior pituitary gland
Adrenal gland
Thyroid gland
Pancreas
Adrenal gland
Aldosterone is secreted by the adrenal gland, specifically the adrenal cortex.
Example Question #4 : Endocrine System
A person with low blood calcium will have increased activity in which gland?
Pituitary gland
Parathyroid glands
Thyroid gland
Pancreas
Parathyroid glands
Blood calcium levels are controlled primarily by the thyroid and parathyroid glands. The parathyroid glands secrete parathyroid hormone (or PTH), which raises blood calcium levels, while the thyroid gland decreases blood calcium levels via the hormone calcitonin. Since the person currently has low blood calcium, the goal is to raise the blood calcium to normal levels. As a result, we can expect to see increased activity in the parathyroid glands.
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