The necessary genotype for a female zygote is XX.

The mother will share this XX genotype (since she is also female) and will contribute one X-chromosome. The father, however, will be male and have the genotype XY. This means he has a 50% chance of passing on an X-chromosome and a 50% chance of passing on a Y-chromosome. If the zygote inherits a Y-chromosome from the father's sperm, then the offspring will be male. If the zygote inherits an X-chromosome from the father's sperm, then the resulting genotype will be XX and the offspring will be female.

Totipotent cells have the ability to propogate and differentiate into any cell types, including the trophoblast. They are different from stem cells, which could be considered multipotent (able to differentiate into multiple tissue types) or pleuripotent (able to differentiate into any major tissue type, but cannot create trophoblast). The only truly totipotent cells are the first two blastomeres.

Most cells contain a complete genome, but not all genes are activated in each cell. Activation of particular genes produces appropriate protein function.

The endoderm develops into a number of internal organs, including the lung, which are vital for breathing.

The kidneys (urine production), muscles (movement), and blood vessels (blood circulation) develop from the mesoderm. The brain (thought) develops from the ectoderm.

This question is targeting your knowledge of the circulatory system. Since the medication has a short half-life, it is necessary that it be carried by the patient's blood stream to the tumor as quickly as possible. Blood travels through the right side of the heart, to the lungs, through the left side of the heart, then to the body. Therefore, inhalation of a chemical would require the least amount of traveling (Lungs, Left Atrium, Left Ventricle, Body). Each other method of administration, including IV, would require more time to travel to the brain. For example, for the IV answer choice, the pathway would be Vein, Right Atrium, Right Ventricle, Lungs, Left Atrium, Left Ventricle, Body.

At puberty, the oocytes arrested at birth in meiosis I resume growth. This most often happens once a month, if fertilization has not occurred, and continues from puberty until menopause. The oocytes arrested at birth complete meiosis I, and are then arrested in meiosis II until fertilization occurs. During ovulation, the follicle ruptures and develops into the corpus luteum. Without fertilization, the endometrium is shed and the cycle continues. Once menopause is reached, this cycle ceases and most often women are no longer fertile.

Follicles are stimulated to grow when FSH level rises. The follicles produce estrogen that exerts a positive feedback on LH, whose levele begin to rise. When LH levels peak on the 14th day of the cycle, the follicle ruptures, releasing the egg from the ovary and leaving the corpus luteum behind in the ovary. After ovulation, the corpus luteum secretes both estrogen and progesterone to inhibit GnRH. When GnRH is inhibited, FSH and LH will also be inhibited. 

The most likely localization of the toxin would be to the ovaries, since this is where gamete production begins for females. For males, gametes are produced in the testes. The incorrect answers are all parts of the female reproductive system. The oviduct is where fertilization takes place. The endometrium (the lining of the uterus) is where the embryo will eventually implant.

Follicle-stimulating hormone stimulates the growth of granulosa cells surrounding the primary oocyte within the ovary, which further promotes maturity of the immature follicle. Prolactin is the hormone that promotes milk production from mammary glands during pregnancy. In females, luteinizing hormone (LH) supports theca cells in the ovaries, which subsequently give rise to precursors to estrogen production. Thyroid hormones regulate metabolism by increasing basal metabolic rate. 

The corpus luteum is the remnant structure of the secondary follicle after the egg is released during ovulation. It secretes progesterone following this process. The other structures do not release appreciable amounts of progesterone; the primary follicle differentiates into the secondary follicle, which in turn releases the ovum, or the egg. The spermatozoon is involved with the fertilization of the egg, and does not release any progesterone.